Exotic alloy metal heat exchangers are difficult to maintain due to rapid particulate, foulant or sludge buildup during use. By contrast, the hybrid frame heat exchanger eliminates the flat surfaces upon which the salts can settle. Designed for ultrapure and aggressive chemical heating and cooling, the hybrid frame heat exchanger has design geometry for efficient heat transfer. In addition, the materials of construction have a lower surface energy surface than metal or other plastics, which inhibits particle buildup. The hybrid heat exchanger provides a large between-tube spacing for free, unrestricted fluid flow. It allows intimate contact between the fluid and the hot or cold heat exchange surfaces, maximizing heat transfer efficiency.